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From Chania airport follow the route: Airport – Souda – Rethymno. More specific: 7 km from the airport you turn left to Souda. Then enter the high way with direction to Rethymnon..
From Heraklion Airport follow the wide road which runs from the airport exit to the National Road . The first exit onto the National Road will take you into the lane heading to Rethymnon.
Exit Atsipopoulo/Rethymno (it is the last Rethymnon exit if you are coming from Heraklion and the first Rethymnon exit if you are coming from Chania)
Take a taxi or a bus from airport to the central bus station of each city. From Chania to Rethymnon it takes about 1h 15min and from Heraklion to Rethymno 1h30m. Bus timetable http://www.bus-service-crete-ktel.com/timetable.php